Phospho-FLT3 (Y589/591) Polyclonal Antibody | G-AB-12589
- 3 to 5 Working Days
Phospho-FLT3 (Y589/591) Polyclonal Antibody | G-AB-12589 | Gentaur Antibodies
Overview: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Category Type: Phosphorylated antibody
Research Areas: Immunology, Signal Transduction
Synonyms: FLT3, CD135, FLK-2, FLK2, STK1
Gene ID: 2322
Immunogen: A synthetic phosphorylated peptide around Y589 & Y591 of human FLT3 (NP_004110.2) .
Calculated MW: 108 kDa/112 kDa
Observed MW: 113 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.