GNAS Polyclonal Antibody | G-AB-02013
Gentaur Antibodies
- SKU:
- G-AB-02013
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
GNAS Polyclonal Antibody | G-AB-02013 | Gentaur Antibodies
Overview: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical Signal Transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Metabolism, Signal Transduction
Synonyms: AHO, GSA, GSP, POH, GPSA, NESP, GNAS1, PHP1A, PHP1B, PHP1C, C20orf45
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #: BC002722
Clonality: Polyclonal
Immunogen: Recombinant protein of human GNAS
Clone #:
Conjugation: Unconjugated
Swissprot: P63092
Santa Cruz: sc-26766/sc-46975/sc-46976/sc-18989/sc-18993/sc-18987/sc-823/sc-98548
Calculated MW: 46 kDa
Observed MW:
Concentration: 0.4 mg/mL
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Application: WB, IHC, ELISA
Dilution: WB 1:200-1:1000, IHC 1:25-1:100
Storage: Store at -20°C. Avoid freeze / thaw cycles.