GNAS Polyclonal Antibody | G-AB-02013

GNAS Polyclonal Antibody | G-AB-02013 | Gentaur Antibodies

Overview: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical Signal Transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Signal Transduction

Synonyms: AHO, GSA, GSP, POH, GPSA, NESP, GNAS1, PHP1A, PHP1B, PHP1C, C20orf45

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC002722

Clonality: Polyclonal

Immunogen: Recombinant protein of human GNAS

Clone #:

Conjugation: Unconjugated

Swissprot: P63092

Santa Cruz: sc-26766/sc-46975/sc-46976/sc-18989/sc-18993/sc-18987/sc-823/sc-98548

Calculated MW: 46 kDa

Observed MW:

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:200-1:1000, IHC 1:25-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

GNAS Polyclonal Antibody DataSheet