MDC1 Polyclonal Antibody | G-AB-01447

MDC1 Polyclonal Antibody | G-AB-01447 | Gentaur Antibodies

Overview: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: Homologue to Drosophila photoreceptor protein calphotin, MDC 1, Mdc1, MDC1, Mediation of DNA damage checkpoint 1, Mediator of DNA damage checkpoint 1, Mediator of DNA damage checkpoint protein 1, NFBD 1, NFBD1, Nuclear factor with BRCT domains 1, Nuclear Factor with BRCT Domains Protein 1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_055456

Clonality: Polyclonal

Immunogen: Synthetic peptide of human MDC1

Clone #:

Conjugation: Unconjugated

Swissprot: Q14676

Santa Cruz: sc-27737

Calculated MW:

Observed MW:

Concentration: 1.2 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:100-1:300

Storage: Store at -20°C. Avoid freeze / thaw cycles.

MDC1 Polyclonal Antibody DataSheet