MDC1 Polyclonal Antibody | G-AB-12158

MDC1 Polyclonal Antibody | G-AB-12158 | Gentaur Antibodies

Overview: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: MDC1, NFBD1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 9656

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human MDC1 (NP_055456.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q14676

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC, IF

Dilution: IHC 1:100-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

MDC1 Polyclonal Antibody DataSheet