NOG Polyclonal Antibody | G-AB-04888

NOG Polyclonal Antibody | G-AB-04888 | Gentaur Antibodies

Overview: NOG (Noggin) is a Protein Coding gene. Diseases associated with NOG include Tarsal-Carpal Coalition Syndrome and Brachydactyly, Type B2. Among its related pathways are Mesodermal Commitment Pathway and Differentiation Pathway. GO annotations related to this gene include protein homodimerization activity and cytokine binding.The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4) . The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Developmental Biology, Stem Cells

Synonyms: Nog, NOGG, Noggin, SYM 1, SYM1, Symphalangism 1 (proximal) , Synostoses (multiple) syndrome 1, SYNS 1, SYNS1

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP005441

Clonality: Polyclonal

Immunogen: Synthetic peptide of human NOG

Clone #:

Conjugation: Unconjugated

Swissprot: Q13253

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1.4 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NOG Polyclonal Antibody DataSheet