NOG Polyclonal Antibody | G-AB-12129
- 3 to 5 Working Days
- Mouse, Rat
NOG Polyclonal Antibody | G-AB-12129 | Gentaur Antibodies
Overview: The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4) . By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Developmental Biology, Stem Cells
Synonyms: NOG, SYM1, SYNS1, SYNS1A, noggin
Reactivity: Mouse, Rat
Gene ID: 9241
Immunogen: Recombinant fusion protein of human NOG (NP_005441.1) .
Calculated MW: 25 kDa
Observed MW: 28 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.