NOTCH4 Polyclonal Antibody | G-AB-12127

NOTCH4 Polyclonal Antibody | G-AB-12127 | Gentaur Antibodies

Overview: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Stem Cells

Synonyms: NOTCH4, INT3, notch 4

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 4855

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human NOTCH4 (NP_004548.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q99466

Santa Cruz:

Calculated MW: 39 kDa/61 kDa/209 kDa

Observed MW: 88 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NOTCH4 Polyclonal Antibody DataSheet