NOTCH4 Polyclonal Antibody | G-AB-12127
- 3 to 5 Working Days
- Human, Mouse, Rat
NOTCH4 Polyclonal Antibody | G-AB-12127 | Gentaur Antibodies
Overview: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Stem Cells
Synonyms: NOTCH4, INT3, notch 4
Reactivity: Human, Mouse, Rat
Gene ID: 4855
Immunogen: Recombinant fusion protein of human NOTCH4 (NP_004548.3) .
Calculated MW: 39 kDa/61 kDa/209 kDa
Observed MW: 88 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.