Pan-AKT Polyclonal Antibody | G-AB-09750

Pan-AKT Polyclonal Antibody | G-AB-09750 | Gentaur Antibodies

Overview: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene./This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: AKT1/AKT2/AKT3

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 207/208/10000

Accession #:

Clonality:

Immunogen: A synthetic peptide of human AKT1/AKT2/AKT3

Clone #:

Conjugation: Unconjugated

Swissprot: P31749, P31751, Q9Y243

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Pan-AKT Polyclonal Antibody DataSheet