Pan-Akt Polyclonal Antibody | G-AB-05855
Gentaur Antibodies
Write a Review
Gentaur Antibodies
Pan-Akt Polyclonal Antibody | G-AB-05855
- SKU:
- G-AB-05855
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
Pan-Akt Polyclonal Antibody | G-AB-05855 | Gentaur Antibodies
Overview: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity) . General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI (3) K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF) , epidermal growth factor (EGF) , insulin and insulin-like growth factor I (IGF-I) . Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Neuroscience, Signal Transduction
Synonyms: AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT2, RAC-beta serine/threonine-protein kinase, Protein kinase Akt-2, Protein kinase B
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #:
Clonality: Polyclonal
Immunogen: Synthesized peptide derived from human Pan-Akt around the non-phosphorylation site of Thr308.
Clone #:
Conjugation: Unconjugated
Swissprot: P31749, P31751, Q9Y243
Santa Cruz:
Calculated MW: 56 kDa
Observed MW: 65 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification method: Affinity purification
Application: WB, IHC-p, ELISA
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Related Products
