Pepsinogen II Polyclonal Antibody | G-AB-10187

Pepsinogen II Polyclonal Antibody | G-AB-10187 | Gentaur Antibodies

Overview: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Microbiology, Signal Transduction

Synonyms: PGC, PEPC, PGII, gastricsin

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5225

Accession #:

Clonality:

Immunogen: A synthetic peptide of human Pepsinogen II (NP_001159896.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P20142

Santa Cruz:

Calculated MW: 34 kDa/42 kDa

Observed MW: 45-50 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Pepsinogen II Polyclonal Antibody DataSheet

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