Phospho-PTPN11 (Y542) Polyclonal Antibody | G-AB-12543

Phospho-PTPN11 (Y542) Polyclonal Antibody | G-AB-12543 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Neuroscience, Signal Transduction

Synonyms: BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, PTPN11

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5781

Accession #:

Clonality:

Immunogen: A phospho specific peptide corresponding to residues surrounding Y542 of human PTPN11

Clone #:

Conjugation: Unconjugated

Swissprot: Q06124

Santa Cruz:

Calculated MW: 52 kDa/68 kDa

Observed MW: 72 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-PTPN11 (Y542) Polyclonal Antibody DataSheet