Phospho-PKCalpha (S319) Polyclonal Antibody | G-AB-12599
- 3 to 5 Working Days
- Human, Mouse, Rat
Phospho-PKCalpha (S319) Polyclonal Antibody | G-AB-12599 | Gentaur Antibodies
Overview: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca (2+) handling in myocytes.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Cardiovascular, Signal Transduction
Synonyms: PRKCA, AAG6, PKC-alpha, PKCA, PRKACA, PKC alpha
Reactivity: Human, Mouse, Rat
Gene ID: 5578
Immunogen: A synthetic phosphorylated peptide around S319 of human PKCalpha (NP_002728.2) .
Calculated MW: 76 kDa
Observed MW: 100 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.