Phospho-SMC1A (S957) Polyclonal Antibody | G-AB-12509
- 3 to 5 Working Days
- Human, Mouse, Rat
Phospho-SMC1A (S957) Polyclonal Antibody | G-AB-12509 | Gentaur Antibodies
Overview: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Cell Biology
Synonyms: SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Reactivity: Human, Mouse, Rat
Gene ID: 8243
Immunogen: A synthetic phosphorylated peptide around S957 of human SMC1A (NP_006297.2) .
Calculated MW: 143 kDa
Observed MW: 160 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IF
Dilution: WB 1:500-1:2000 IF 1:20-1:100
Storage: Store at -20°C. Avoid freeze / thaw cycles.