PRKAB1 Polyclonal Antibody | G-AB-11946
Gentaur Antibodies
- SKU:
- G-AB-11946
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
PRKAB1 Polyclonal Antibody | G-AB-11946 | Gentaur Antibodies
Overview: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR) , key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction
Synonyms: PRKAB1, AMPK, HAMPKb
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID: 5564
Accession #:
Clonality:
Immunogen: A synthetic peptide of human PRKAB1
Clone #:
Conjugation: Unconjugated
Swissprot: Q9Y478
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: IHC
Dilution: IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.