PTPN6 Polyclonal Antibody | G-AB-08689

PTPN6 Polyclonal Antibody | G-AB-08689 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Developmental Biology, Signal Transduction

Synonyms: HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, CTCN6, PTPN6

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5777

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human PTPN6 (NP_002822.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P29350

Santa Cruz:

Calculated MW: 63 kDa/67 kDa/70 kDa

Observed MW: 68 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IF

Dilution: WB 1:500-1:2000 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PTPN6 Polyclonal Antibody DataSheet