RAF1 Polyclonal Antibody | G-AB-00202
Gentaur Antibodies
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Gentaur Antibodies
RAF1 Polyclonal Antibody | G-AB-00202
- SKU:
- G-AB-00202
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human
RAF1 Polyclonal Antibody | G-AB-00202 | Gentaur Antibodies
Overview: This gene is the cellular homolog of viral raf gene (v-raf) . The encoded protein is a MAP kinase kinase kinase (MAP3K) , which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cell Biology, Metabolism, Signal Transduction
Synonyms: c Raf, C-raf, CMD1NN, Craf 1 transforming gene, cRaf, Craf1 transforming gene, EC 2.7.11.1, kinase Raf1, Murine sarcoma 3611 oncogene 1, NS5, Oncogene MIL, Oncogene RAF1, OTTHUMP00000160218, Protein kinase raf 1, Raf 1, Raf 1 proto oncogene serine/threonine kinase, RAF, Raf proto oncogene serine/threonine protein kinase, RAF proto-oncogene serine/threonine-protein kinase, Similar to murine leukemia viral (V-raf-1) oncogene homolog 1, TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV, v raf 1 murine leukemia viral oncogene homolog 1
Reactivity: Human
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #:
Clonality: Polyclonal
Immunogen: Recombinant Human RAF proto-oncogene serine/threonine-protein kinase protien
Clone #:
Conjugation: Unconjugated
Swissprot: P04049
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 2 mg/mL
Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Purification method: Affinity purification
Application: IHC
Dilution: IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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