SMAD7 Polyclonal Antibody | G-AB-06949
Gentaur Antibodies
- SKU:
- G-AB-06949
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
SMAD7 Polyclonal Antibody | G-AB-06949 | Gentaur Antibodies
Overview: SMAD7, also named as Mothers against decapentaplegic homolog 7, is a 426 amino acid protein, which belongs to the dwarfin/SMAD family. SMAD7 Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693) . TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236) . SMAD7 as antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. SMAD7 functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex and also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. SMAD7 positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction
Synonyms: CRCS3, FLJ16482, hSMAD 7, hSMAD7, MAD (mothers against decapentaplegic Drosophila) homolog 7, MAD, Mad homolog 7, MAD homolog 8, MAD mothers against decapentaplegic homolog 7, MADH 7, MADH 8, MADH6, MADH8, Mothers Against Decapentaplegic Drosophila Homolog of 6, Mothers Against Decapentaplegic Drosophila Homolog of 7, Mothers against decapentaplegic homolog 7, Mothers against decapentaplegic homolog 8, Mothers against DPP homolog 7, Mothers against DPP homolog 8, SMA- AND MAD-RELATED PROTEIN 7, SMAD 7, SMAD, SMAD family member 7, SMAD, mothers against DPP homolog 7 (Drosophila) , SMAD, mothers against DPP homolog 7, SMAD6, Smad7, SMAD7
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #: NP001177750
Clonality: Polyclonal
Immunogen: Synthetic peptide of human SMAD7
Clone #:
Conjugation: Unconjugated
Swissprot: O15105
Santa Cruz:
Calculated MW: 46 kDa
Observed MW: Refer to figures
Concentration: 1.14 mg/mL
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification method: Antigen affinity purification
Application: WB, IHC, ELISA
Dilution: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000
Storage: Store at -20°C. Avoid freeze / thaw cycles.