TLR3 Polyclonal Antibody | G-AB-07629

TLR3 Polyclonal Antibody | G-AB-07629 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology, Microbiology, Signal Transduction

Synonyms: TLR3, CD283, IIAE2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 7098

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human TLR3 (NP_003256.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: O15455

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

TLR3 Polyclonal Antibody DataSheet