ABCC5 Polyclonal Antibody | G-AB-07663

ABCC5 Polyclonal Antibody | G-AB-07663 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9- (2-phosphonylmethoxyethyl) adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Signal Transduction

Synonyms: ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 10057

Accession #:

Clonality:

Immunogen: A synthetic peptide of human ABCC5 (NP_005679.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: O15440

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ABCC5 Polyclonal Antibody DataSheet