ABL1 Polyclonal Antibody | G-AB-00380
- 3 to 5 Working Days
- Human, Rat
ABL1 Polyclonal Antibody | G-AB-00380 | Gentaur Antibodies
Overview: The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t (9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Category Type: Polyclonal Antibody
Research Areas: Signal Transduction, Epigenetics and Nuclear Signaling, Cancer
Synonyms: Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine protein kinase 1, Abl 1, ABL, bcr/abl, c ABL, c abl oncogene 1 receptor tyrosine kinase, JTK7, p150, Proto-oncogene c-Abl, Tyrosine-protein kinase ABL1, v abl
Reactivity: Human, Rat
Gene ID: 25
Immunogen: Recombinant Human Tyrosine-protein kinase ABL1 protein
Concentration: 0.24 mg/mL
Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3
Purification method: Antigen Affinity Purification
Dilution: IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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