ACHE Polyclonal Antibody | G-AB-10192

ACHE Polyclonal Antibody | G-AB-10192 | Gentaur Antibodies

Overview: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Neuroscience

Synonyms: ACHE, ACEE, ARACHE, N-ACHE, YT

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 43

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ACHE (NP_056646.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P22303

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ACHE Polyclonal Antibody DataSheet

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