ALDH2 Polyclonal Antibody | G-AB-08256

ALDH2 Polyclonal Antibody | G-AB-08256 | Gentaur Antibodies

Overview: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction, Tags & Cell Markers

Synonyms: ALDH2, ALDH-E2, ALDHI, ALDM

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 217

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ALDH2 (NP_000681.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P05091

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ALDH2 Polyclonal Antibody DataSheet