ALIX / PDCD6IP Polyclonal Antibody | G-AB-10017

ALIX / PDCD6IP Polyclonal Antibody | G-AB-10017 | Gentaur Antibodies

Overview: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Microbiology, Signal Transduction

Synonyms: PDCD6IP, AIP1, ALIX, DRIP4, HP95

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 10015

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ALIX / PDCD6IP (NP_037506.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q8WUM4

Santa Cruz:

Calculated MW: 30 kDa/96 kDa

Observed MW: 105 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:200-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ALIX / PDCD6IP Polyclonal Antibody DataSheet