ALOX5 Polyclonal Antibody | G-AB-09981

ALOX5 Polyclonal Antibody | G-AB-09981 | Gentaur Antibodies

Overview: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5 (S) -hydroperoxy-6-trans-8, 11, 14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5 (S) -trans-7, 9-trans-11, 14-cis-eicosatetrenoic acid (leukotriene A4) . Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms: ALOX5, 5-LO, 5-LOX, 5LPG, LOG5

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 240

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ALOX5 (NP_000689.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P09917

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC, IF

Dilution: IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ALOX5 Polyclonal Antibody DataSheet