AMPK alpha2 Polyclonal Antibody | G-AB-00216
- 3 to 5 Working Days
- Human, Rat
AMPK alpha2 Polyclonal Antibody | G-AB-00216 | Gentaur Antibodies
Overview: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR) , key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction
Synonyms: 5'-AMP-activated protein kinase catalytic subunit alpha-2, AAPK2, ACACA kinase, Acetyl-CoA carboxylase kinase, AMPK alpha 2 chain, AMPK subunit alpha-2, AMPK2, AMPKa2, AMPKalpha2, HMGCR kinase, Hydroxymethylglutaryl-CoA reductase kinase, PRKAA, PRKAA2, Protein kinase AMP activated alpha 2 catalytic subunit, Protein kinase AMP activated catalytic subunit alpha 2
Reactivity: Human, Rat
Immunogen: Recombinant Rat 5'-AMP-activated protein kinase catalytic subunit alpha-2 protein
Calculated MW: 62, 4 kDa
Observed MW: 62 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Purification method: Antigen Affinity Purification
Application: WB, IHC, IF
Dilution: WB 1:500-1:2000 IHC 1:100-1:200 IF 1:100-1:400
Storage: Store at -20°C. Avoid freeze / thaw cycles.