APAF1 Polyclonal Antibody | G-AB-01199

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$117.36 - $334.80
SKU:
G-AB-01199
Availability:
3 to 5 Working Days
Host:
Rabbit
Reactivity:
Human, Mouse, Rat
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APAF1 Polyclonal Antibody | G-AB-01199 | Gentaur Antibodies

Overview: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD) , and an ATPase domain (NB-ARC) . Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Metabolism

Synonyms: APAF 1, Apaf-1, APAF, Apaf1, Apoptotic peptidase activating factor 1, Apoptotic protease activating factor 1, Apoptotic protease activating factor, Apoptotic protease-activating factor 1, CED 4, CED4, KIAA0413

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_863659

Clonality: Polyclonal

Immunogen: Synthetic peptide of human APAF1

Clone #:

Conjugation: Unconjugated

Swissprot: O14727

Santa Cruz: sc-7231/sc-26685/sc-7232/sc-33870/sc-33871/sc-65890/sc-65891/sc-65890/sc-65891/sc-8339

Calculated MW: 142 kDa

Observed MW:

Concentration: 0.7 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

APAF1 Polyclonal Antibody DataSheet

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