ARHGEF3 Polyclonal Antibody | G-AB-12232
- 3 to 5 Working Days
- Human, Mouse
ARHGEF3 Polyclonal Antibody | G-AB-12232 | Gentaur Antibodies
Overview: Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD) , indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Category Type: Polyclonal Antibody
Research Areas: Metabolism, Signal Transduction
Synonyms: ARHGEF3, GEF3, STA3, XPLN
Reactivity: Human, Mouse
Gene ID: 50650
Immunogen: Recombinant fusion protein of human ARHGEF3 (NP_062455.1) .
Calculated MW: 36 kDa/59 kDa/60 kDa/63 kDa
Observed MW: 60 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IHC
Dilution: WB 1:500-1:2000 IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.