ASK1 Polyclonal Antibody | G-AB-10315

ASK1 Polyclonal Antibody | G-AB-10315 | Gentaur Antibodies

Overview: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK) , MAPK kinase (MKK or MEK) , and MAPK kinase kinase (MAPKKK or MEKK) . MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1, 374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK) /stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Cardiovascular

Synonyms: MAP3K5, ASK1, MAPKKK5, MEKK5

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 4217

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ASK1 (NP_005914.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q99683

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ASK1 Polyclonal Antibody DataSheet