BCAS3 Polyclonal Antibody | G-AB-11595

BCAS3 Polyclonal Antibody | G-AB-11595 | Gentaur Antibodies

Overview: BCAS3 (breast carcinoma amplified sequence 3) , also designated MAAB or GAOB1, is a 913 amino acid protein that is believed to be involved in breast cancer progression. The gene is regulated by ER (estrogen receptor alpha) and expressed in multiple tissues, including malignant human brain lesions. It is overexpressed and amplified in breast cancer cell lines. BCAS3 contains three WD40 repeat regions, a bromodomain, a rare zinc-finger motif, four probable DNA-binding domains, and two kinase-inducible phosphorylation domains. Five variants are produced due to alternative splicing. BCAS3 interacts with histone H3 and PCAF, which is indicative of histone acetyltransferase activity. BCAS3 also exhibits ER transactiviation activity by acting as a coactivator with PELP1 or MTA1. The amplification and translocation between the BCAS3 gene and the BCAS4 gene results in a fusion transcript is overexpressed in MCF-7 cells.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Stem Cells

Synonyms: BCAS3, GAOB1, MAAB

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 54828

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human BCAS3 (NP_060149.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9H6U6

Santa Cruz:

Calculated MW: 74 kDa/99 kDa/101 kDa/102 kDa/103 kDa

Observed MW: 115 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

BCAS3 Polyclonal Antibody DataSheet