BCR Polyclonal Antibody | G-AB-00371
Gentaur Antibodies
- SKU:
- G-AB-00371
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
BCR Polyclonal Antibody | G-AB-00371 | Gentaur Antibodies
Overview: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Category Type: Polyclonal Antibody
Research Areas: Signal Transduction, Cancer
Synonyms: ALL, bcr, BCR1, Breakpoint cluster region, CML, D22S11, D22S662, PHL, Renal carcinoma antigen NY-REN-26
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID: 613
Accession #:
Clonality: Polyclonal
Immunogen: Recombinant Human Breakpoint cluster region protein
Clone #:
Conjugation: Unconjugated
Swissprot: P11274
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 1 mg/mL
Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3
Purification method: Antigen Affinity Purification
Application: IHC
Dilution: IHC 1:100-1:300
Storage: Store at -20°C. Avoid freeze / thaw cycles.