BECN1 Monoclonal Antibody | G-AB-05710
- 3 to 5 Working Days
- Human, Mouse, Rat
BECN1 Monoclonal Antibody | G-AB-05710 | Gentaur Antibodies
Overview: Beclin-1 (BECN1) , also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
Category Type: Monoclonal Antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Microbiology, Signal Transduction
Synonyms: APG6, ATG 6, ATG6, ATG6 autophagy related 6 homolog, Bcl-2-interacting protein beclin, Beclin 1 (coiled coil moesin like BCL2 interacting protein) , Beclin 1 autophagy related, Beclin-1, Beclin1, BECN 1, Becn1, BECN1, Coiled coil myosin like BCL2 interacting protein, Coiled-coil myosin-like BCL2-interacting protein, GT197, Protein GT197, VPS 30, VPS30
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic Peptide of Beclin-1
Clone #: Clone:5A11
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification method: Protein A purification
Dilution: IHC 1:100-200
Storage: Store at -20°C. Avoid freeze / thaw cycles.