BEST1 Polyclonal Antibody | G-AB-10248

BEST1 Polyclonal Antibody | G-AB-10248 | Gentaur Antibodies

Overview: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2) , also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Neuroscience

Synonyms: BEST1, ARB, BEST, BMD, RP50, TU15B, VMD2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 7439

Accession #:

Clonality:

Immunogen: A synthetic peptide of human BEST1 (NP_004174.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: O76090

Santa Cruz:

Calculated MW: 57 kDa/67 kDa/69 kDa

Observed MW: 70 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

BEST1 Polyclonal Antibody DataSheet