BRSK1 Polyclonal Antibody | G-AB-09674

BRSK1 Polyclonal Antibody | G-AB-09674 | Gentaur Antibodies

Overview: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. BRSK1 (BR serine/threonine-protein kinase 1) , also known as SAD1, is a 794 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one UBA domain and one protein kinase domain. Expressed in a variety of tissues with highest expression in testis and brain, BRSK1 uses magensium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins, including Wee 1 and Cdc25B. Via its kinase activity toward proteins that are involved in microtubule assembly, BRSK1 plays an essential role in neuronal polarization and may be involved in regulating cell cycle arrest in response to DNA damage, Two isoforms of BRSK1 exist due to alternative splicing events.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology

Synonyms: BRSK1, hSAD1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 84446

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human BRSK1 (NP_115806.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q8TDC3

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

BRSK1 Polyclonal Antibody DataSheet