CASP1 Polyclonal Antibody | G-AB-05089

CASP1 Polyclonal Antibody | G-AB-05089 | Gentaur Antibodies

Overview: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Metabolism

Synonyms: CASP-1, CASP1, CASP1, Caspase 1, Caspase-1 subunit p10, ICE, IL-1 beta-converting enzyme, IL-1BC, IL1 beta converting enzyme, IL1B convertase, Interleukin 1 beta convertase, Interleukin 1B converting enzyme, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, p45

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC062327

Clonality: Polyclonal

Immunogen: Fusion protein of human CASP1

Clone #:

Conjugation: Unconjugated

Swissprot: P29466

Santa Cruz:

Calculated MW: 45 kDa

Observed MW: Refer to figures

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:1000-1:4000, IHC 1:25-1:100, ELISA 1:1000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CASP1 Polyclonal Antibody DataSheet

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