CASP3 Polyclonal Antibody | G-AB-01900

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$163.00 - $465.00
SKU:
G-AB-01900
Availability:
3 to 5 Working Days
Host:
Rabbit
Reactivity:
Human, Mouse, Rat
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CASP3 Polyclonal Antibody | G-AB-01900 | Gentaur Antibodies

Overview: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Metabolism, Neuroscience

Synonyms: A830040C14Rik, Apopain, CASP-3, CASP3, CASP3, Casp3a, Caspase 3, Caspase 3, apoptosis-related cysteine peptidase, Caspase 3, apoptosis-related cysteine protease, Caspase 3, apoptosis-related cysteine protease a, Caspase-3 subunit p12, CC3, CPP-32, CPP32, CPP32B, Cysteine protease CPP32, EC 3.4.22.56, LICE, mldy, OTTHUMP00000165052, OTTHUMP00000165053, OTTHUMP00000165054, PARP cleavage protease, Procaspase3, Protein Yama, SCA 1, SCA-1, SREBP cleavage activity 1, Yama

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC016926

Clonality: Polyclonal

Immunogen: Recombinant protein of human CASP3

Clone #:

Conjugation: Unconjugated

Swissprot: P42574

Santa Cruz: sc-22139/sc-22140/sc-1224/sc-1226/sc-1225/sc-6138/sc-98785/sc-7148

Calculated MW: 32 kDa

Observed MW:

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:200-1:1000, IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CASP3 Polyclonal Antibody DataSheet

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