Catenin beta Monoclonal Antibody | G-AB-05535

Catenin beta Monoclonal Antibody | G-AB-05535 | Gentaur Antibodies

Overview: Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

Category Type: Monoclonal Antibody

Research Areas: Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells

Synonyms: Beta catenin, Beta-catenin, Cadherin associated protein, Catenin (cadherin associated protein) , beta 1, 88kDa, Catenin beta 1, Catenin beta-1, CATNB, CHBCAT, CTNB1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, OTTHUMP00000162082, OTTHUMP00000165222, OTTHUMP00000165223, OTTHUMP00000209288, OTTHUMP00000209289

Reactivity: Human, Mouse, Rat

Host: Mouse

Isotype: IgG

Gene ID:

Accession #:

Clonality: Monoclonal

Immunogen: Synthetic Peptide

Clone #: Clone:1F5

Conjugation: Unconjugated

Swissprot: P35222

Santa Cruz:

Calculated MW: 85 kDa

Observed MW: 92 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification method: Protein A purification

Application: WB, IHC-p

Dilution: WB 1:1000-1:2000, IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Catenin beta Monoclonal Antibody DataSheet