CD40 Polyclonal Antibody | G-AB-08135

CD40 Polyclonal Antibody | G-AB-08135 | Gentaur Antibodies

Overview: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the Signal Transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) . Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Immunology, Stem cells

Synonyms: CD40, Bp50, CDW40, TNFRSF5, p50

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 958

Accession #:

Clonality:

Immunogen: A Synthetic peptide of human CD40

Clone #:

Conjugation: Unconjugated

Swissprot: P25942

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CD40 Polyclonal Antibody DataSheet