CD59 Polyclonal Antibody | G-AB-09574

CD59 Polyclonal Antibody | G-AB-09574 | Gentaur Antibodies

Overview: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte Signal Transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in Signal Transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Immunology, Signal Transduction, Stem Cells

Synonyms: CD59, 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 966

Accession #:

Clonality:

Immunogen: Recombinant protein of human CD59

Clone #:

Conjugation: Unconjugated

Swissprot: P13987

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CD59 Polyclonal Antibody DataSheet