CEMIP Polyclonal Antibody | G-AB-12283
- 3 to 5 Working Days
- Human, Mouse
CEMIP Polyclonal Antibody | G-AB-12283 | Gentaur Antibodies
Overview: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT) , and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Neuroscience
Synonyms: CEMIP, CCSP1, HYBID, KIAA1199, TMEM2L
Reactivity: Human, Mouse
Gene ID: 57214
Immunogen: Recombinant fusion protein of human CEMIP (NP_061159.1) .
Calculated MW: 110 kDa/152 kDa
Observed MW: 180 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IHC
Dilution: WB 1:500-1:2000 IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.