CHRNA2 Polyclonal Antibody | G-AB-03104

CHRNA2 Polyclonal Antibody | G-AB-03104 | Gentaur Antibodies

Overview: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.

Category Type: Polyclonal Antibody

Research Areas: Neuroscience

Synonyms: ACHA2, AChR, Cholinergic receptor nicotinic alpha 2, Chrna2, Neuronal acetylcholine receptor protein subunit alpha 2, Neuronal acetylcholine receptor subunit alpha-2

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_000733

Clonality: Polyclonal

Immunogen: Synthetic peptide of human CHRNA2

Clone #:

Conjugation: Unconjugated

Swissprot: Q15822

Santa Cruz: sc-5589

Calculated MW: 60 kDa

Observed MW:

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CHRNA2 Polyclonal Antibody DataSheet