CKMT1B Polyclonal Antibody | G-AB-10254

CKMT1B Polyclonal Antibody | G-AB-10254 | Gentaur Antibodies

Overview: Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: CKMT1B, CKMT, CKMT1, UMTCK

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 1159

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CKMT1B (NP_066270.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P12532

Santa Cruz:

Calculated MW: 47 kDa/50 kDa

Observed MW: 40 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CKMT1B Polyclonal Antibody DataSheet