COL18A1 Polyclonal Antibody | G-AB-09673

COL18A1 Polyclonal Antibody | G-AB-09673 | Gentaur Antibodies

Overview: This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Signal Transduction

Synonyms: COL18A1, KNO, KNO1, KS

Reactivity: Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 80781

Accession #:

Clonality:

Immunogen: A synthetic peptide of human COL18A1 (NP_085059.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P39060

Santa Cruz:

Calculated MW: 135 kDa/154 kDa/178 kDa

Observed MW: 240 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:1000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

COL18A1 Polyclonal Antibody DataSheet