Complement Factor B Polyclonal Antibody | G-AB-09627

Complement Factor B Polyclonal Antibody | G-AB-09627 | Gentaur Antibodies

Overview: This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

Category Type: Polyclonal Antibody

Research Areas: Immunology

Synonyms: CFB, AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 629

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human Complement Factor B (NP_001701.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P00751

Santa Cruz:

Calculated MW: 68 kDa/85 kDa

Observed MW: 86 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Complement Factor B Polyclonal Antibody DataSheet