COMT Polyclonal Antibody | G-AB-07986

COMT Polyclonal Antibody | G-AB-07986 | Gentaur Antibodies

Overview: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT) . The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Neuroscience, Signal Transduction

Synonyms: COMT, HEL-S-98n

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 1312

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human COMT (NP_009294.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P21964

Santa Cruz:

Calculated MW: 24 kDa/30 kDa

Observed MW: 25 kDa/30 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

COMT Polyclonal Antibody DataSheet