CRACR2A Polyclonal Antibody | G-AB-08447
Gentaur Antibodies
Write a Review
Gentaur Antibodies
CRACR2A Polyclonal Antibody | G-AB-08447
- SKU:
- G-AB-08447
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
CRACR2A Polyclonal Antibody | G-AB-08447 | Gentaur Antibodies
Overview: Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Category Type: Polyclonal Antibody
Research Areas: Signal Transduction
Synonyms: CRACR2A, EFCAB4B
Reactivity: Human, Mouse
Host: Rabbit
Isotype: IgG
Gene ID: 84766
Accession #:
Clonality:
Immunogen: Recombinant fusion protein of human CRACR2A (NP_001138430.1) .
Clone #:
Conjugation: Unconjugated
Swissprot: Q9BSW2
Santa Cruz:
Calculated MW: 45 kDa/83 kDa
Observed MW: 45 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IHC
Dilution: WB 1:500-1:2000 IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Related Products
