CTSF Polyclonal Antibody | G-AB-07397

CTSF Polyclonal Antibody | G-AB-07397 | Gentaur Antibodies

Overview: Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: CTSF, CATSF, CLN13

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 8722

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CTSF (NP_003784.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9UBX1

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CTSF Polyclonal Antibody DataSheet