DCC Polyclonal Antibody | G-AB-02873

DCC Polyclonal Antibody | G-AB-02873 | Gentaur Antibodies

Overview: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms: Colorectal cancer related chromosome sequence 18, Colorectal cancer suppressor, CRC 18, CRC18, CRCR 1, CRCR1, DCC, DCC, Deleted in colorectal cancer protein, Deleted in colorectal carcinoma, Immunoglobulin superfamily DCC subclass member 1, Netrin receptor DCC, Tumor suppressor protein DCC

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_005206

Clonality: Polyclonal

Immunogen: Synthetic peptide of human DCC

Clone #:

Conjugation: Unconjugated

Swissprot: P43146

Santa Cruz: sc-6534/sc-6535/sc-11437

Calculated MW:

Observed MW:

Concentration: 0.7 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

DCC Polyclonal Antibody DataSheet