DCX Polyclonal Antibody | G-AB-08743

DCX Polyclonal Antibody | G-AB-08743 | Gentaur Antibodies

Overview: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Neuroscience, Tags & Cell Markers

Synonyms: DBCN, DC, LISX, SCLH, XLIS, DCX

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 1641

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human DCX (NP_835364.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: O43602

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

DCX Polyclonal Antibody DataSheet